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Related Experiment Video

Updated: Sep 3, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

P63 and P73 Activation in Cancers with p53 Mutation.

Bi-He Cai¹, Yun-Chien Hsu¹, Fang-Yu Yeh¹

¹School of Medicine, I-Shou University, No. 8, Yida Rd., Jiaosu Village Yanchao District, Kaohsiung 82445, Taiwan.

|July 27, 2022

Summary

This review explores drug therapies for p53 mutations, a key tumor suppressor. It discusses targeting p53, p63, and p73 for cancer treatment, focusing on missense and nonsense mutations.

Keywords:

aggregation anti-cancer drugs gain of function mutation p53 p63 p73

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Last Updated: Sep 3, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53

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Published on: August 4, 2019

Establishment of a Clinic-based Biorepository

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Published on: May 29, 2017

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Area of Science:

Oncology
Molecular Biology
Genetics

Background:

The p53 family (p53, p63, p73) has tumor suppressor roles.
p53 exhibits high mutation rates in cancers, losing its suppressor function.
Missense and nonsense mutations are the most common p53 alterations.

Purpose of the Study:

To review potential drug therapies for p53 missense and nonsense mutations.
To explore the therapeutic potential of p63 and p73 activators as anti-cancer agents.
To summarize p63 and p73 activators and strategies to enhance their efficacy, especially for p53 gain-of-function mutants.

Main Methods:

Literature review of existing research on p53 family mutations.
Analysis of drug therapies targeting specific p53 mutations (missense, nonsense).
Summary of p63 and p73 activators and their mechanisms.

Main Results:

p53 mutations impair tumor suppression, necessitating therapeutic interventions.
p63 and p73 activators show promise as alternative anti-cancer strategies.
Strategies for improving activator responses against p53 gain-of-function mutants are discussed.

Conclusions:

Targeting p53 mutations and utilizing p63/p73 activators represent viable therapeutic avenues in oncology.
Further research into enhancing p63/p73 activator efficacy is crucial for effective cancer treatment.
Understanding p53 family dynamics is key to developing novel anti-cancer drugs.