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Exploring the Links between Obesity and Psoriasis: A Comprehensive Review
Gabriela Barros1, Pablo Duran2, Ivana Vera2
1Departamento de Post-Grado, Universidad Católica de Cuenca, Ciudad Cuenca 010109, Ecuador.
International Journal of Molecular Sciences
|July 27, 2022
Summary
Obesity and psoriasis share common inflammatory pathways, influenced by diet, lifestyle, genetics, and the microbiome. Managing inflammation in obesity offers a potential therapeutic target for psoriasis.
Area of Science:
- Immunology
- Metabolic Disorders
- Dermatology
Background:
- Obesity is a global health concern linked to chronic diseases like type 2 diabetes, dyslipidemias, atherosclerosis, cancers, and skin conditions such as psoriasis.
- The connection between obesity and psoriasis is multifactorial, involving diet, lifestyle, genetics, and the microbiome, all contributing to a chronic inflammatory state.
Purpose of the Study:
- To provide a comprehensive overview of the relationship between obesity and psoriasis.
- To explore the molecular mechanisms linking these two conditions.
- To discuss recent therapeutic advancements for managing obesity-related psoriasis.
Main Methods:
- Literature review of scientific evidence.
- Analysis of molecular pathways involved in inflammation.
- Examination of the role of adipose tissue secretome.
- Review of current and emerging therapeutic strategies.
Main Results:
- Obesity and psoriasis share a common pro-inflammatory state.
- Adipose tissue dysfunction and immune dysregulation are key links.
- Diet, lifestyle, genetics, and microbiome significantly influence both conditions.
Conclusions:
- Targeting inflammation in obesity is a promising strategy for psoriasis treatment.
- Understanding the molecular interplay is crucial for developing effective therapies.
- Further research into therapeutic advances is warranted.
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