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Updated: Sep 3, 2025

Evaluation of the Storage Stability of Extracellular Vesicles
Published on: May 22, 2019
Extracellular Vesicles-Oral Therapeutics of the Future
Martyna Cieślik1, Katarzyna Nazimek1, Krzysztof Bryniarski1
1Department of Immunology, Jagiellonian University Medical College, 18 Czysta St., 31-121 Krakow, Poland.
Abstract:
Considered an artifact just after discovery, the possibility of oral delivery of extracellular vesicles (EVs) and their functional cargos has recently gained much research attention. EVs from various sources, including edible plants, milk, bacteria and mammalian cells, have emerged as a platform for miRNA and drug delivery that seem to induce the expected immune effects locally and in distant tissues after oral administration. Such a possibility greatly expands the clinical applicability of EVs. The present review summarizes research findings that either support or deny the biological/therapeutical activity of orally administered EVs and their role in cross-species and cross-kingdom signaling.
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