The Diagnosis and Management of Cardiometabolic Risk and Cardiometabolic Syndrome after Spinal Cord Injury

Gary J Farkas1,2, Adam M Burton3, David W McMillan2,4

  • 1Department of Physical Medicine and Rehabilitation, School of Medicine, University of Miami Miller, Miami, FL 33136, USA.

Insights

Spinal cord injuries (SCI) increase risks for cardiometabolic syndrome (CMS), including obesity and hypertension, raising cardiovascular disease threats. This review covers SCI-related cardiometabolic risks, diagnosis, and management strategies.

Area of Science:

  • Neurology
  • Cardiology
  • Metabolic Medicine

Background:

  • Spinal cord injury (SCI) patients frequently develop risk factors for cardiometabolic syndrome (CMS).
  • Obesity, dyslipidemia, dysglycemia, and hypertension are common in SCI, increasing cardiovascular disease (CVD) risk.
  • CVD is a leading cause of mortality following SCI.

Purpose of the Study:

  • To review current data on cardiometabolic risk, CMS, and CVD in SCI.
  • To examine the etiopathogenesis of these conditions post-SCI.
  • To provide updated diagnostic and management guidelines.

Main Methods:

  • This narrative review synthesizes recent research (last 5 years) on cardiometabolic sequelae in SCI.
  • It examines the underlying mechanisms (etiopathogenesis) of these conditions.
  • It compiles current diagnostic criteria and surveillance guidelines.

Main Results:

  • Individuals with SCI exhibit multiple cardiometabolic risk factors, contributing to CMS.
  • These factors significantly elevate the risk of developing cardiovascular disease.
  • Recent research highlights the complex interplay between SCI and metabolic dysfunction.

Conclusions:

  • Cardiometabolic risk and CMS are significant concerns after SCI, driving CVD mortality.
  • Early diagnosis, surveillance, and targeted lifestyle interventions are crucial.
  • A novel obesity classification and updated management strategies are proposed.

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