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Bacteria and Dry Eye: A Narrative Review.
Yuchen Wang1, Yi Ding2, Xiaodan Jiang1
1Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Department of Ophthalmology, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China.
Journal of Clinical Medicine
|July 27, 2022
Summary
Bacterial communities on the ocular surface differ between dry eye patients and the general population. This review explores bacterial mechanisms in dry eye pathogenesis and potential therapeutic targets.
Area of Science:
- Ophthalmology
- Microbiology
- Immunology
Background:
- Dry eye disease (DED) is a prevalent, multifactorial condition affecting the ocular surface.
- Increasing incidence of DED highlights the need to understand its pathogenesis, particularly the role of bacterial flora.
- Exploring novel treatment strategies for DED is crucial.
Purpose of the Study:
- To systematically review and summarize bacterial differences between DED patients and the general population.
- To elucidate the mechanisms by which bacteria contribute to DED development.
- To identify potential therapeutic targets for DED.
Main Methods:
- Comprehensive literature review of over 100 studies.
- Analysis of bacterial communities on the ocular surface in general and DED populations.
- Examination of the relationship between DED and antibiotic therapy.
Main Results:
- Significant differences in ocular surface bacterial communities were observed between DED patients and healthy individuals.
- A correlation between DED and antibiotic therapy was identified.
- Potential pathogenic mechanisms include disruption of the antibacterial barrier, microbiome imbalance, inflammation, and vitamin deficiency.
Conclusions:
- Bacterial dysbiosis plays a significant role in the pathogenesis of dry eye disease.
- Understanding these bacterial mechanisms offers new avenues for DED treatment.
- Further research into microbiome-targeted therapies is warranted.
