Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Lytic Cycle of Bacteriophages01:30

Lytic Cycle of Bacteriophages

71.7K
Bacteriophages, also known as phages, are specialized viruses that infect bacteria. A key characteristic of phages is their distinctive “head-tail” morphology. A phage begins the infection process (i.e., lytic cycle) by attaching to the outside of a bacterial cell. Attachment is accomplished via proteins in the phage tail that bind to specific receptor proteins on the outer surface of the bacterium. The tail injects the phage’s DNA genome into the bacterial cytoplasm. In the...
71.7K
DNA Bacteriophages01:26

DNA Bacteriophages

127
Bacteriophages, or phages, are viruses that specifically infect bacteria, utilizing their genetic material to hijack host cellular machinery for replication. DNA bacteriophages employ single-stranded DNA (ssDNA) or double-stranded DNA (dsDNA) genomes. These phages exhibit diverse replication strategies and host interactions, influencing their ecological roles and applications in biotechnology and medicine.ssDNA BacteriophagesssDNA phages, with their small genomes, utilize unique strategies to...
127
Lysogenic Cycle of Bacteriophages00:43

Lysogenic Cycle of Bacteriophages

63.0K
In contrast to the lytic cycle, phages infecting bacteria via the lysogenic cycle do not immediately kill their host cell. Instead, they combine their genome with the host genome, allowing the bacteria to replicate the phage DNA along with the bacterial genome. The incorporated copy of the phage genome is called the prophage. Some prophages can re-activate and enter the lytic cycle. This often occurs in response to a perturbation, such as DNA damage, but can also transpire in the absence of...
63.0K
Viral Replication: Lysogenic Cycle01:16

Viral Replication: Lysogenic Cycle

178
The lysogenic cycle is a crucial viral replication strategy that allows bacteriophages to persist within host cells without immediately destroying them. This process is primarily observed in temperate phages, such as bacteriophage lambda (λ), which infects Escherichia coli. The cycle allows the viral genome to persist across bacterial generations while keeping host cells viable.Integration of the Viral GenomeUpon infection, bacteriophage lambda attaches to the bacterial surface and injects...
178
Viral Replication: Lytic Cycle01:20

Viral Replication: Lytic Cycle

186
Bacteriophages, or phages, are viruses that specifically infect bacteria. Among them, T-even bacteriophages, such as T4, exhibit a well-characterized lytic replication cycle in Escherichia coli (E. coli). This process ensures the rapid proliferation of the virus while ultimately leading to the destruction of the bacterial host.Attachment and DNA InjectionThe infection process begins with the recognition and binding of the T4 phage to the E. coli cell surface. Tail fibers of the phage...
186
Viruses of Archaea01:29

Viruses of Archaea

70
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
70

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In Vitro Susceptibility of Clinical and Carrier Strains of <i>Staphylococcus aureus</i> to STAFAL<sup>®</sup> Phage Preparation.

International journal of molecular sciences·2024
Same author

Is It Time to Start Worrying? A Comprehensive Report on the Three-Year Prevalence of ESBL-Producing Bacteria and Their Trends in Antibiotic Resistance from the Largest University Hospital in Slovakia.

Pharmaceuticals (Basel, Switzerland)·2024
Same author

Carbapenem-Resistant <i>Klebsiella pneumoniae</i> in COVID-19 Era-Challenges and Solutions.

Antibiotics (Basel, Switzerland)·2023
Same author

Moving toward Extensively Drug-Resistant: Four-Year Antimicrobial Resistance Trends of <i>Acinetobacter baumannii</i> from the Largest Department of Internal Medicine in Slovakia.

Antibiotics (Basel, Switzerland)·2023
Same author

High Emergence of Multidrug-Resistant Sequence Type 131 Subclade C2 among Extended-Spectrum β-Lactamase (ESBL)-Producing <i>Escherichia coli</i> Isolated from the University Hospital Bratislava, Slovakia.

Antibiotics (Basel, Switzerland)·2023
Same author

Next-Generation Sequencing of Carbapenem-Resistant <i>Klebsiella pneumoniae</i> Strains Isolated from Patients Hospitalized in the University Hospital Facilities.

Antibiotics (Basel, Switzerland)·2022
Same journal

Correction: Peptine et al. Methicillin-Resistant <i>Staphylococcus aureus</i> (MRSA) and Vancomycin-Resistant Enterococci (VRE) in Nosocomial Infections: A Systematic Review of Resistance, Pathogenesis, and Clinical Management. <i>Microorganisms</i> 2026, <i>14</i>, 428.

Microorganisms·2026
Same journal

Torque Teno Virus (TTV) Plasma Load and Immune Reconstitution in People Living with HIV: A Systematic Review.

Microorganisms·2026
Same journal

Optimizing Bacteriophage Screening and Isolation Methods for Microbial Samples Derived from Different Body Sites of Cattle.

Microorganisms·2026
Same journal

Enhanced Biphenyl Degradation by <i>Rhodococcus</i> sp. TG-1 Under Cr(VI) Stress via Modified Biochar Immobilization.

Microorganisms·2026
Same journal

In Vitro Detection of Biologically Active Staphylococcal Enterotoxins Type B and C1 as an Alternative to In Vivo Testing.

Microorganisms·2026
Same journal

Monitoring Hygiene Protocols and Exploring Alternatives to Counteract Resistant Pathogens: A Case Study from Southern Italy on Healthcare-Associated Infection Control.

Microorganisms·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.3K

Phascinating Phages.

Marek Straka1,2, Martina Dubinová1,3, Adriána Liptáková1

  • 1Medical Faculty, Institute of Microbiology, Comenius University in Bratislava, 81108 Bratislava, Slovakia.

Microorganisms
|July 27, 2022
PubMed
Summary
This summary is machine-generated.

Bacteriophage (phage) therapy offers a promising alternative to antibiotics for treating drug-resistant bacterial infections. This review explores phage biology, competition mechanisms, and the pros and cons of phage therapy, supported by lab and clinical data.

Keywords:
antibiotic therapybacteriophagesdrug-resistant bacteriaphage therapy

More Related Videos

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

2.0K
Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
07:19

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides

Published on: June 28, 2024

1.1K

Related Experiment Videos

Last Updated: Sep 3, 2025

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins
09:40

Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins

Published on: June 11, 2015

12.3K
Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics
09:23

Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics

Published on: January 5, 2024

2.0K
Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides
07:19

Author Spotlight: Efficiently Eliminating Bacteriophages from Infected Salmonella Cultures Using Lipopolysaccharides

Published on: June 28, 2024

1.1K

Area of Science:

  • Microbiology
  • Virology
  • Infectious Diseases

Background:

  • Rising antimicrobial resistance poses a significant global health threat.
  • Conventional antibiotic treatments are becoming less effective against resistant bacterial strains.
  • Bacteriophage (phage) therapy, using viruses that infect bacteria, is an emerging alternative.

Purpose of the Study:

  • To review the principles of bacteriophage biology and their application in therapy.
  • To discuss the mechanisms of bacterial and phage competition.
  • To evaluate the benefits and drawbacks of phage therapy for treating bacterial infections.

Main Methods:

  • Literature review of phage biology and therapy.
  • Analysis of laboratory experiments on phage efficacy.
  • Examination of clinical case studies involving phage therapy.

Main Results:

  • Bacteriophages are natural bacterial predators with a long history of use in some regions.
  • Phage therapy presents a viable alternative to antibiotics, particularly for resistant infections.
  • Both laboratory and clinical data support the potential of phage therapy.

Conclusions:

  • Phage therapy is a promising strategy to combat antimicrobial resistance.
  • Further research and clinical application in Western countries are underway.
  • Understanding phage-bacterial interactions is crucial for effective therapeutic development.