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Two Natural Flavonoid Substituted Polysaccharides from Tamarix chinensis: Structural Characterization and
Yukun Jiao1, Yiting Yang1, Lishuang Zhou1
1School of Pharmacy, Institutes of Integrative Medicine, Fudan University, Shanghai 201203, China.
Molecules (Basel, Switzerland)
|July 27, 2022
Summary
Two novel flavonoid-substituted polysaccharides from Tamarix chinensis, MBAP-1 and MBAP-2, demonstrated significant anticomplement and antioxidant activities. MBAP-1 showed greater potency, suggesting its potential as a therapeutic agent.
Area of Science:
- Natural Product Chemistry
- Immunology
- Biochemistry
Background:
- Polysaccharides are complex carbohydrates with diverse biological activities.
- Flavonoids are plant-derived compounds known for their antioxidant and anti-inflammatory properties.
- Tamarix chinensis is a plant species with traditional medicinal uses.
Purpose of the Study:
- To isolate and characterize novel flavonoid-substituted polysaccharides from Tamarix chinensis.
- To evaluate the anticomplement and antioxidant activities of these compounds.
- To investigate the structure-activity relationship of these polysaccharides.
Main Methods:
- HPGPC, methylation, UPLC-IT-MSn, and NMR analysis were used for structural characterization.
- Anticomplement activity was assessed by measuring the 50% hemolytic complement (CH50) in vitro.
- Antioxidant activity was evaluated using standard assays.
Main Results:
- Two homogenous flavonoid-substituted polysaccharides, MBAP-1 and MBAP-2, were successfully isolated and characterized.
- Both MBAP-1 and MBAP-2 exhibited anticomplement activity, with MBAP-1 being more potent.
- MBAP-1 also displayed superior antioxidant activity compared to MBAP-2.
Conclusions:
- The novel flavonoid-substituted polysaccharides MBAP-1 and MBAP-2 from Tamarix chinensis possess significant anticomplement and antioxidant properties.
- MBAP-1 demonstrates higher potency, indicating potential therapeutic applications.
- Structural features, including monosaccharide composition and uronic acids, likely contribute to the observed bioactivities.
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