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Involvement of Resveratrol against Brain Cancer: A Combination Strategy with a Pharmaceutical Approach

Chenmala Karthika1, Agnieszka Najda2, Joanna Klepacka3

  • 1Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty 643001, India.

Molecules (Basel, Switzerland)
|July 27, 2022
PubMed

Insights

This review explores brain tumors (BTs), discussing challenges in diagnosis and treatment. It highlights resveratrol

Area of Science:

  • Neuro-oncology
  • Pharmacology
  • Nanomedicine

Background:

  • Brain tumors (BTs) present diagnostic and therapeutic challenges, often diagnosed late.
  • Current treatments for brain diseases have significant side effects.
  • Understanding BT mechanisms and drug delivery is crucial for effective treatment.

Purpose of the Study:

  • To review the concept, barriers, and delivery methods for targeting brain tumors.
  • To explore the potential of resveratrol, a potent antioxidant, in treating brain diseases.
  • To investigate combination therapy with resveratrol for brain disorders.

Main Methods:

  • Literature review focusing on brain tumor concepts and treatment barriers.
  • Analysis of resveratrol's properties and its correlation with brain disease treatment.
  • Discussion of nanomedicine and drug delivery systems for brain disorders.

Main Results:

  • Identified challenges in brain tumor diagnosis and drug development.
  • Highlighted the potential benefits of resveratrol as an antioxidant for brain diseases.
  • Explored the role of the blood-brain barrier and multi-drug resistance in treatment efficacy.

Conclusions:

  • Resveratrol shows promise as a component in combination therapy for brain disorders.
  • Nanomedicine offers potential solutions for targeted drug delivery across the blood-brain barrier.
  • Further investigation into resveratrol-based combination therapies and advanced drug delivery is warranted.
Keywords:
P-glycoproteinantioxidantsblood–brain barrierbrain tumornasal deliveryresveratrol

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