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Therapeutic Cancer Vaccines-Antigen Discovery and Adjuvant Delivery Platforms

Neftali Ortega Alarcon1, Maddy Jaramillo1, Heidi M Mansour1,2,3,4

  • 1Skaggs Pharmaceutical Sciences Center, College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA.

Pharmaceutics
|July 27, 2022
PubMed

Insights

Therapeutic subunit vaccines show promise for cancer immunotherapy by utilizing tumor antigens and pattern recognition receptor (PRR)-targeting adjuvants. Combining multiple adjuvants enhances their effectiveness in cancer treatment.

Area of Science:

  • Immunology
  • Oncology
  • Vaccinology

Background:

  • Vaccines are crucial for infectious disease prevention and show potential in cancer treatment.
  • Therapeutic subunit vaccines represent a key strategy in cancer immunotherapy.

Purpose of the Study:

  • To review the progress of therapeutic subunit vaccines for cancer immunotherapy.
  • To summarize tumor antigens, neoantigen identification, and adjuvant strategies.

Main Methods:

  • Literature review focusing on therapeutic subunit vaccines for cancer.
  • Summarization of tumor antigen classes and bioinformatic neoantigen identification.
  • Discussion of pattern recognition receptor (PRR)-targeting adjuvants and delivery platforms.

Main Results:

  • Several classes of tumor antigens and methods for neoantigen identification were summarized.
  • Pattern recognition receptor (PRR)-targeting adjuvants and their delivery systems were discussed.
  • The importance of combining multiple adjuvants for enhanced cancer immunotherapy was highlighted.

Conclusions:

  • Therapeutic subunit vaccines are advancing cancer immunotherapy.
  • Strategic use of tumor antigens and PRR-targeting adjuvants is critical.
  • Combined adjuvant strategies offer enhanced therapeutic potential for cancer treatment.
Keywords:
adjuvantscombination therapiesdelivery systemstherapeutic vaccinetumor antigens

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