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The Blood-brain Barrier00:49

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Opening the Blood Brain Barrier with an Electropermanent Magnet System.

Sahar Jafari1, Ittai S Baum1, Oleg G Udalov1

  • 1Weinberg Medical Physics, Inc., North Bethesda, MD 20852, USA.

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|July 27, 2022
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Summary

Researchers used novel electropermanent magnets to open the blood-brain barrier (BBB) in vitro and in vivo. Monophasic magnetic pulses effectively opened the BBB, suggesting potential for new brain disorder treatments.

Keywords:
blood brain barrierelectropermanent magnetmagnetic resonance imaging

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Opening the blood-brain barrier (BBB) is crucial for treating brain disorders.
  • Magnetic fields can potentially induce electric fields for safe BBB opening.

Purpose of the Study:

  • To investigate the efficacy of electropermanent magnets (EPMs) for opening the BBB.
  • To compare monophasic and biphasic electrical pulses for BBB opening.

Main Methods:

  • Utilized a novel EPM array to generate tunable magnetic pulses.
  • Tested BBB opening in a model culture in vitro.
  • Confirmed BBB opening in vivo using contrast-enhanced MRI.

Main Results:

  • Demonstrated BBB tight junction opening in vitro with tuned magnetic pulses.
  • Monophasic electrical pulses were more effective than biphasic ones for BBB opening.
  • Successfully opened the BBB in vivo using monophasic pulses, confirmed by MRI.

Conclusions:

  • EPMs can effectively open the BBB with precisely timed monophasic electrical pulses.
  • Suggests potential for a hybrid EPM-based theragnostic device for simultaneous brain imaging and drug delivery.
  • This approach may advance treatments for various brain disorders.