Cell and Animal Models for SARS-CoV-2 Research.

Area of Science:

• Virology
• Pharmacology
• Preclinical Research

Background:

• The COVID-19 pandemic necessitated rapid development of antiviral drugs and vaccines against SARS-CoV-2.
• Understanding SARS-CoV-2 pathophysiology and identifying therapeutic targets are key to effective treatment strategies.

Purpose of the Study:

• To review available preclinical models for SARS-CoV-2 research.
• To evaluate the advantages, drawbacks, and relevance of these models for drug effectiveness testing.

Main Methods:

• Review of scientific literature on SARS-CoV-2 preclinical models.
• Analysis of cell-based and animal model systems.

Main Results:

• Various cell-based and animal models have been developed to mimic SARS-CoV-2 infection.
• Each model possesses unique strengths and limitations for studying viral disease and testing therapeutics.

Conclusions:

• Appropriate selection of preclinical models is essential for accurate assessment of antiviral drug efficacy.
• Continued refinement of experimental models will accelerate the development of effective COVID-19 treatments.