Related Experiment Video
Updated: Sep 3, 2025
17:15
Catheterization of Intestinal Loops in Ruminants
Published on: June 11, 2009
13.7K
Immunopathological Changes Post-Infection with Enterobacter cloacae in Rabbits.
S R S Al-Eqabi1, Z Ismail Ibrahim2, Z Jamal Mohammed Jawad2
1Department of Public Health, College of Veterinary Medicine, Wasit University, Wasit, Iraq.
Archives of Razi Institute
|July 27, 2022
Summary
This study reveals that Enterobacter cloacae infection in rabbits causes significant immune responses and pathological damage, including organ lesions and inflammation. These findings highlight the severe health impacts of nosocomial infections.
Area of Science:
- Veterinary Pathology
- Infectious Diseases
- Immunology
Background:
- Nosocomial infections pose significant health risks to both humans and animals.
- Enterobacter cloacae is a notable cause of hospital-acquired infections.
Purpose of the Study:
- To investigate the pathogenesis of Enterobacter cloacae following intraperitoneal inoculation in rabbits.
- To evaluate the immunological and pathological effects of E. cloacae infection in a rabbit model.
Main Methods:
- 42 rabbits were divided into an infected group (E. cloacae intraperitoneal inoculation) and a control group (phosphate buffer saline).
- Animals were sacrificed at 48/72 hours and 7 days post-infection for analysis.
- Tumor Necrosis Factor-alpha (TNF-α) levels and pathological lesions in vital organs were assessed.
Main Results:
- A significant increase in TNF-α concentration was observed in the infected group.
- Pathological lesions, including vascular congestion, edema, and polymorphonuclear neutrophil infiltration, were identified in the lungs, kidneys, and heart of infected rabbits.
- These findings represent the first detailed observation of E. cloacae pathological changes in rabbit organs.
Conclusions:
- Enterobacter cloacae infection induces a notable inflammatory response, evidenced by increased TNF-α.
- The bacterium causes significant pathological alterations in vital organs, underscoring its virulence.
- This study provides crucial insights into the pathogenesis of E. cloacae in a mammalian model.
