Related Experiment Video
Updated: Sep 3, 2025

Characterizing Cell Migration Within Three-dimensional In Vitro Wound Environments
Published on: August 16, 2017
The Role of the Extracellular Matrix (ECM) in Wound Healing: A Review
Robert B Diller1, Aaron J Tabor1
1Department of Biological Sciences, Northern Arizona University, Flagstaff, AZ 86011, USA.
Abstract:
The extracellular matrix (ECM) is a 3-dimensional structure and an essential component in all human tissues. It is comprised of varying proteins, including collagens, elastin, and smaller quantities of structural proteins. Studies have demonstrated the ECM aids in cellular adherence, tissue anchoring, cellular signaling, and recruitment of cells. During times of integumentary injury or damage, either acute or chronic, the ECM is damaged. Through a series of overlapping events called the wound healing phases-hemostasis, inflammation, proliferation, and remodeling-the ECM is synthesized and ideally returned to its native state. This article synthesizes current and historical literature to demonstrate the involvement of the ECM in the varying phases of the wound healing cascade.
Related Concept Videos
The Extracellular Matrix
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Extracellular Matrix
Role of Matrix Metalloproteases in Degradation of ECM
Overview of Cell-Matrix Interactions
Cell-matrix's Response to Mechanical Forces
Anchoring junctions mechanically attach a cell to the...

