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A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis
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Global Spread of MCR-Producing Salmonella enterica Isolates

Zengfeng Zhang1, Xiaorong Tian1, Chunlei Shi1

  • 1MOST-USDA Joint Research Center for Food Safety, School of Agriculture and Biology, and State Key Laboratory of Microbial Metabolism, Shanghai Jiao Tong University, Shanghai 200240, China.

Antibiotics (Basel, Switzerland)
|July 27, 2022
PubMed

Insights

Colistin resistance in Salmonella, driven by mobile mcr genes, is a global threat. This study reveals widespread mcr-producing Salmonella in humans, food, and animals across 37 countries, highlighting international spread challenges.

Area of Science:

  • Microbiology
  • Genomics
  • Food Safety

Background:

  • Colistin resistance in bacteria, primarily due to mobile mcr genes, poses a significant threat to public health.
  • Understanding the prevalence and spread of these resistance genes in foodborne pathogens like Salmonella enterica is crucial.

Purpose of the Study:

  • To determine the global prevalence and molecular characteristics of mcr-producing Salmonella enterica isolates.
  • To investigate the sources, serotypes, mcr variants, and phylogenetic relationships of these resistant bacteria.

Main Methods:

  • Bioinformatic analysis of 2279 mcr-producing Salmonella genomes from public databases.
  • Identification of Salmonella serotypes, mcr gene variants, and co-resistance genes.
  • Phylogenetic analysis to infer global dissemination patterns.

Main Results:

  • mcr-producing Salmonella were found in 37 countries across five continents, predominantly in human (39.5%) and food (32.6%) samples.
  • Typhimurium and 1,4,[5],12:i:- were the most common serotypes, with mcr-9.1 (65.2%) and mcr-1.1 (24.4%) being the predominant variants.
  • Phylogenetic analysis indicated international spread, with isolates from different countries intermingling in key lineages.

Conclusions:

  • mcr-carrying Salmonella are globally disseminated, posing significant challenges to food safety and public health.
  • The mixed phylogenetic lineages suggest extensive international transmission, necessitating enhanced surveillance and control strategies.
Keywords:
Salmonellamcr genesphylogenetic analysis

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