On the modelling of human growth

Area of Science:

• Human growth and development
• Endocrinology
• Biomathematics

Background:

• Accurate modeling of human linear growth is crucial for understanding developmental biology and identifying growth disorders.
• Existing models may not fully capture the distinct physiological and hormonal influences on different growth phases.
• A need exists for a growth model that aligns with known endocrinological regulation patterns.

Purpose of the Study:

• To introduce a new mathematical model for human linear growth from birth to maturity.
• To develop a model that integrates distinct growth phases based on endocrinological regulation.
• To enable the isolated analysis of infancy, childhood, and puberty growth components.

Main Methods:

• Development of a new additive model for human linear growth.
• Decomposition of growth into three distinct components: infancy, childhood, and puberty.
• Alignment of model components with established endocrinological regulation features.

Main Results:

• Presentation of the ICP-model, incorporating infancy, childhood, and puberty as additive growth components.
• Demonstration that model components correspond to known endocrinological regulation of growth.
• Establishment of the capability to consider each growth component in isolation.

Conclusions:

• The ICP-model provides a novel framework for analyzing human linear growth.
• The model's structure reflects the endocrinological regulation of distinct developmental stages.
• This approach facilitates a more nuanced understanding of human growth dynamics.