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Updated: Sep 3, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gastrointestinal Tract Microbiome Effect and Role in Disease Development
Neira Crnčević1, Mirsada Hukić2,3, Sara Deumić1
1Department of Genetics and Bioengineering, International Burch University, Francuske revolucije bb, Ilidža, 71210 Sarajevo, Bosnia and Herzegovina.
Diseases (Basel, Switzerland)
|July 27, 2022
Summary
Gastrointestinal microflora imbalance impacts chronic diseases and cancers. Advanced diagnostics improve detection of conditions like small intestine bacterial overgrowth (SIBO).
Area of Science:
- Microbiology
- Gastroenterology
- Oncology
Background:
- Gastrointestinal microflora significantly influences chronic disease development.
- Microbial imbalances are linked to autism, celiac disease, Crohn's disease, diabetes, and small bowel cancers.
- Factors like genetics, lifestyle, and antibiotic overuse disrupt gut microbiota.
Purpose of the Study:
- To review the impact of the gastrointestinal environment on chronic disease severity.
- To explore the role of gut microbiota in cancer development.
- To summarize current understanding of small intestine bacterial overgrowth (SIBO).
Main Methods:
- Literature review of studies on gastrointestinal microflora and chronic diseases.
- Analysis of factors contributing to microbial imbalance.
- Discussion of diagnostic advancements for SIBO.
Main Results:
- Gut microbiota dysbiosis is associated with numerous chronic diseases and cancers.
- Small intestine bacterial overgrowth (SIBO) is a condition linked to hypochlorhydria and small intestine cancers.
- Emerging diagnostic tools like capsule endoscopy enhance SIBO detection.
Conclusions:
- Maintaining a healthy gut microbiome is crucial for preventing chronic diseases and cancers.
- SIBO requires further investigation due to its association with specific conditions.
- Technological advancements are improving the diagnosis and management of gastrointestinal disorders.
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