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What Are the Minimal Feeds Required for Starting Enteral Ibuprofen in Preterm Infants with PDA?

Aimann Surak1, Abbas Hyderi1

  • 1Northern Alberta Neonatal Program, Philip C. Etches NICU, Royal Alexandra Hospital Site, DTC 5027, 10240 Kingsway NW, Edmonton, AB T5H 3V9, Canada.

Pediatric Reports
|July 27, 2022
PubMed

Insights

Oral ibuprofen shows higher closure rates and improved safety for patent ductus arteriosus (PDA) in preterm infants over 26 weeks gestation. Canadian centers lack consensus on feeding volumes before ibuprofen administration, leading to variable practices.

Area of Science:

  • Neonatal medicine
  • Pediatric pharmacology

Background:

  • Patent ductus arteriosus (PDA) is a common condition in preterm infants.
  • Ibuprofen is a frequently used treatment for hemodynamically significant PDA.

Purpose of the Study:

  • To evaluate the efficacy and safety of oral ibuprofen for PDA treatment in preterm infants.
  • To explore current practices regarding enteral feeding volumes before ibuprofen administration in Canadian centers.

Main Methods:

  • Review of existing literature on oral ibuprofen for PDA.
  • Survey or analysis of current practices in Canadian neonatal centers regarding feeding protocols before ibuprofen.

Main Results:

  • Oral ibuprofen demonstrates a higher closure rate compared to other formulations.
  • A better safety profile is observed with oral ibuprofen in infants born after 26 weeks' gestation.
  • Significant variation exists among Canadian centers regarding the minimum enteral feed volume required before initiating ibuprofen for PDA.

Conclusions:

  • Oral ibuprofen is an effective and safe option for treating PDA in preterm infants > 26 weeks gestation.
  • Current practices for initiating ibuprofen are inconsistent across Canadian centers, highlighting a need for standardized guidelines.

Keywords:
PDAibuprofenpreterm

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