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Overview of Piperine: Bioactivities, Total Synthesis, Structural Modification, and Structure-Activity Relationships
Shaochen Li1,2, Min Lv2, Hui Xu1,2
1School of Marine Sciences, Ningbo University, Ningbo 315211, Zhejiang Province, P. R. China.
Mini Reviews in Medicinal Chemistry
|July 27, 2022
Summary
Piperine, a natural alkaloid, and its derivatives show diverse biological activities including antitumor and insecticidal properties. This review covers recent advances in their bioactivity, synthesis, and structural modifications.
Area of Science:
- Medicinal Chemistry
- Natural Products Chemistry
- Pharmacology
Background:
- Natural products are crucial for identifying new drug and pesticide candidates.
- Piperine, an alkaloid from Piperaceae plants, exhibits various biological activities.
- Recent research has explored piperine's bioactivity, mechanisms, synthesis, and structural modifications.
Approach:
- This review summarizes research on piperine and its derivatives from 2014 to 2020.
- It covers advancements in biological activities, mechanisms of action, total synthesis, and structural modifications.
- Structure-activity relationships are also discussed.
Key Points:
- Piperine derivatives demonstrate significant antitumor, anti-inflammatory, antioxidant, neuroprotective, and insecticidal activities.
- Recent synthetic strategies and structural modifications aim to enhance piperine's therapeutic potential.
- Understanding structure-activity relationships is key to designing more potent analogs.
Conclusions:
- Piperine and its derivatives represent a promising class of compounds for drug and pesticide development.
- Further research into their mechanisms and structure-activity relationships will facilitate the discovery of novel therapeutic agents.
- This review provides a comprehensive overview of recent progress in the field.
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