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Published on: July 28, 2023
683
Recent advances in nanotechnology mediated mitochondria-targeted imaging
Nannan Zheng1, Qinghui Wang1, Shijin Zhang1
1School of Medicine and Health, Key Laboratory of Microsystems and Microstructures Manufacturing (Ministry of Education), Harbin Institute of Technology, Harbin, 150001, China. liangcanhe@hit.edu.cn.
Journal of Materials Chemistry. B
|July 27, 2022
Summary
Nanotechnology enables precise targeting and imaging of mitochondria, crucial for understanding cell metabolism and diseases like cancer. This review explores recent advancements in nanoprobes for monitoring mitochondrial function and dynamics.
Area of Science:
- Biomedical Engineering
- Cell Biology
- Nanotechnology
Background:
- Mitochondria are vital for cellular growth and metabolism.
- Mitochondrial dysfunction is linked to diseases including cancers and neurodegenerative disorders.
- Monitoring mitochondrial dynamics and function is critical for disease diagnosis and treatment.
Purpose of the Study:
- To provide an overview of recent developments in nanotechnology-mediated mitochondrial imaging probes.
- To classify these probes based on their targeting strategies (membrane vs. microenvironment).
- To discuss the impact, applications, and future perspectives of these nanoprobes.
Main Methods:
- Review of current literature on nanotechnology-based mitochondrial probes.
- Classification of probes into mitochondrial membrane-targeting and microenvironment-targeting categories.
- Analysis of probe design, construction, and application in biological research.
Main Results:
- Nanotechnology offers flexible, versatile, and effective methods for mitochondrial targeting and imaging.
- Various nanoprobes have been developed, leveraging different nanotechnology pathways.
- Probes are designed to target specific mitochondrial structures or the surrounding microenvironment.
Conclusions:
- Nanotechnology-based imaging probes are essential tools for studying mitochondrial dynamics and function.
- Continued innovation in nanoprobes will advance our understanding of mitochondrial roles in health and disease.
- Future research holds promise for novel therapeutic and diagnostic applications.
