Immune Cell and Biochemical Biomarkers in Advanced Laryngeal Cancer

Area of Science:

• Oncology
• Immunology
• Biomarker Research

Background:

• Advanced laryngeal carcinoma presents a significant challenge in treatment selection.
• Identifying reliable prognostic biomarkers is crucial for optimizing patient outcomes.

Purpose of the Study:

• To evaluate cell (CD4, CD8) and biochemical (IL-6, IL-8, CRP) biomarkers.
• To establish the prognostic value of these biomarkers in advanced laryngeal cancer.

Main Methods:

• Prospective study of 52 surgically treated advanced laryngeal cancer patients.
• Immunohistochemical staining for CD4 and CD8 T-cell markers in tumor tissue.
• Analysis of serum IL-6, IL-8, and C-reactive protein (CRP) levels.

Main Results:

• Three-year overall survival (OS) was 69.2%; disease-specific survival (DSS) was 72.5%.
• Higher CD4+ and CD8+ expression showed univariate prognostic significance but not in multivariate analysis.
• Elevated IL-8 levels were a significant predictor of 3-year OS and DSS; IL-6 and CRP were not.

Conclusions:

• CD4 and CD8 expression did not establish a prognostic role in this cohort.
• Higher IL-8 levels are a significant negative predictor of disease-specific survival.
• Combining biomarkers may improve treatment choice assessment for advanced laryngeal carcinoma.