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Updated: Jul 6, 2026
Using Retinal Imaging to Study Dementia
Published on: November 6, 2017
Posterior pole analysis and ganglion cell layer measurements in Alzheimer's disease
Yasemin Un1, Funda Alpaslan2, Nejla Tukenmez Dikmen3
1Department of Ophthalmology, Istanbul Haydarpasa Numune Training and Research Hospital, Uskudar, Turkey.
Aim:
To compare posterior pole analysis and ganglion cell layer (GCL) of patients with Alzheimer's disease (AD) and controls.
Method:
Patients diagnosed with mild and moderate AD included in the study. Posterior pole analysis and GCL measurements were investigated by dividing the macula into superior and inferior hemifields and 5 corresponding zones.
Results:
There were no significant differences between groups for retinal thickness measurements in any retinal zone. GCL measurements showed lower measurements in moderate AD group for GCL thickness in the superior zone 2 (p:0.025) and inferior zone 2 (p = 0.048) compared to mild AD and controls. A moderate AD status was found to cause a decrease of 5.349 µm in the GCL-SZ2 value [p:0.037].
Conclusion:
GCL measurements in the moderate AD group show significant thinning in superior and inferior Zone 2, which may be a biomarker for AD.
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