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Published on: May 25, 2020

Biometric Parameters and Ganglion Cell Measurements in Children of Patients with Primary Angle-closure Glaucoma

Aylin Huryol1, Yasemin Un2, Ece Turan Vural2

  • 1Department of Ophthalmology, Midyat State Hospital, Mardin, Turkey.

Journal of Current Glaucoma Practice
|August 12, 2026
PubMed

Insights

Children of primary angle-closure glaucoma (PACG) patients have smaller anterior segment dimensions, including anterior chamber depth (ACD) and axial length (AL). However, retinal nerve fiber layer (RNFL) and ganglion cell layer (GCL) thickness remain unaffected, indicating no glaucoma development in offspring.

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Genetics of Eye Diseases

Background:

  • Primary angle-closure glaucoma (PACG) is a significant cause of vision loss.
  • Understanding the ocular characteristics of PACG patients' children is crucial for early detection and prevention.
  • Genetic and environmental factors influence PACG development.

Purpose of the Study:

  • To compare morphometric eye characteristics in young adults (19-40 years) with a parental history of PACG versus healthy controls.
  • To identify potential predisposing ocular features in the offspring of PACG patients.

Main Methods:

  • A cross-sectional study involving 22 prepresbyopic children of PACG patients and 22 age/sex-matched healthy controls.
  • Biometric measurements of the anterior segment and ocular structures using Sirius topography.
  • Key parameters measured: central corneal thickness (CCT), iridocorneal angle (ICA), anterior chamber volume (ACV), anterior chamber depth (ACD), axial length (AL), horizontal anterior chamber diameter (HACD), macular ganglion cell layer (GCL), and peripapillary retinal nerve fiber layer (RNFL).

Main Results:

  • Significantly lower ACD, ACV, ICA, and horizontal anterior chamber diameter (HACD) in the PACG offspring group (p < 0.05).
  • Significantly shorter axial length (AL) in the PACG offspring group (22.99 ± 0.17 mm) compared to controls (23.64 ± 0.17 mm) (p < 0.001).
  • No significant differences in CCT, macular GCL, peripapillary RNFL, or optic disc topography between the groups (p > 0.05).

Conclusions:

  • Prepresbyopic children of PACG patients exhibit smaller anterior segment dimensions (AL, ICA, ACD, ACV, HACD) compared to healthy individuals.
  • Despite anterior segment differences, key retinal and optic nerve structures (GCL, RNFL, optic disc) show no statistically significant differences, suggesting no current glaucomatous changes in this young cohort.
  • These findings highlight potential predisposing morphometric traits in PACG offspring, warranting further longitudinal investigation.
Abstract

Keywords:
Axial lengthChildrenGanglion cell layer thicknessPrimary angle-closure glaucomaSirius topographerSwept-source optical coherence tomography

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