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The relationship between gender and systemic immune-inflammation index in patients with new-onset essential

Emine Altuntas1, Sükrü Cetın1, Songül Usalp1

  • 1Department of Cardiology, Sancaktepe Sehit Prof Dr Ilhan Varank Education and Research Hospital, Istanbul, Turkey.

Cardiovascular Journal of Africa
|July 28, 2022
PubMed

Insights

The systemic immune-inflammation index (SII) is higher in women with hypertension and correlates with age. This finding may help improve survival rates in hypertensive women with cardiovascular diseases.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Gerontology

Background:

  • The systemic immune-inflammation index (SII) shows prognostic value in cardiovascular diseases and cancers.
  • Hypertension is a major risk factor for cardiovascular morbidity and mortality.

Purpose of the Study:

  • To investigate the association between SII and gender and age in newly diagnosed, treatment-naïve hypertensive patients.
  • To explore the potential of SII as a biomarker in hypertension management.

Main Methods:

  • A retrospective study of 153 newly diagnosed, treatment-naïve hypertensive patients (93 men, 60 women).
  • Calculation of SII using the formula: SII = (platelet count × neutrophil count) / lymphocyte count.
  • Analysis of SII levels in relation to gender and age.

Main Results:

  • SII was significantly higher in women than in men (546.31 vs. 385, p=0.003).
  • SII showed a positive correlation with age.
  • A specific SII cut-off value was identified for predicting new-onset essential hypertension in women with 67.6% sensitivity and 67.2% specificity.

Conclusions:

  • The study suggests a potential role for SII in differentiating hypertensive individuals based on gender and age.
  • Elevated SII in women may indicate increased inflammation and could be a marker for cardiovascular risk.
  • The findings support considering SII for improving survival rates in hypertensive women with cardiovascular diseases.
Abstract

Keywords:
agegenderinflammationnewly diagnosed hypertensionsystemic immune‐inflammation index

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