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Medullary carcinoma of jejunum presenting as perforation peritonitis: A case report

Amrita Talwar1, Arvind Ahuja1, Ravi H Phulware2

  • 1Department of Pathology, Post Graduate Institute of Medical Education and Research (PGIMER), Atal Bihari Vajpayee Institute of Medical Sciences (ABVIMS), Ram Manohar Lohia Hospital (RML), New Delhi, India.

Indian Journal of Pathology & Microbiology
|July 28, 2022
PubMed

Insights

Medullary carcinoma (MC) of the small intestine is a rare cancer. This case report details an exceptional jejunal MC presentation with metastasis, highlighting its unique characteristics and potential for better prognosis.

Area of Science:

  • Gastroenterology
  • Oncology
  • Pathology

Background:

  • Medullary carcinoma (MC) is a rare small intestinal carcinoma subtype.
  • Literature review reveals only six previously reported cases of small intestinal MC.

Observation:

  • A 65-year-old male presented with jejunal MC, perforation peritonitis, and liver metastasis.
  • No predisposing factors like inflammatory bowel disease or celiac disease were identified.

Findings:

  • Small intestinal MC is an exceptional entity, rarely reported.
  • While colonic MC often exhibits microsatellite instability (MSI) and BRAF mutations, exceptions exist in this subtype.
  • Small intestinal MC may possess a better prognosis compared to other histological subtypes.

Implications:

  • This case expands the understanding of rare small intestinal malignancies.
  • Further research into the molecular characteristics and prognostic factors of small intestinal MC is warranted.
  • Highlights the need for accurate histological subtyping for appropriate patient management and prognosis.
Keywords:
Intestinal perforationjejunal carcinomaliver metastasismedullary carcinomasmall intestine

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