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Coagulation abnormalities in children with uncorrected congenital heart defects seen at a teaching hospital in a

Omotola O Majiyagbe1,2, Adeseye M Akinsete1,3, Titilope A Adeyemo4

  • 1Department of Paediatrics, Lagos University Teaching Hospital, Lagos, Nigeria.

Plos One
|July 28, 2022
PubMed

Insights

Coagulation abnormalities are common in children with congenital heart defects (CHD). Low oxygen saturation and hematocrit are risk factors, highlighting the need for routine screening in these patients.

Area of Science:

  • Pediatric Cardiology
  • Hematology
  • Congenital Heart Disease Research

Background:

  • Coagulation abnormalities are a major cause of mortality in children with uncorrected congenital heart defects (CHD).
  • Understanding the prevalence and risk factors for these abnormalities is crucial for improving patient outcomes.

Purpose of the Study:

  • To determine the prevalence of coagulation abnormalities in children with uncorrected CHD.
  • To identify factors associated with coagulation abnormalities in this population.

Main Methods:

  • A cross-sectional study involving 70 children with uncorrected CHD and 70 healthy controls.
  • Coagulation status assessed via complete blood count, prothrombin time, activated partial thromboplastin time, and D-dimer assay.

Main Results:

  • Prevalence of coagulation abnormalities was significantly higher in children with CHD (37.1%) compared to controls (7.1%).
  • Children with cyanotic CHD exhibited a higher prevalence (57.1%) than those with acyanotic CHD (17.1%).
  • Hematocrit and oxygen saturation levels were significantly associated with coagulation abnormalities.

Conclusions:

  • Coagulation abnormalities are frequent in children with uncorrected CHD.
  • Oxygen saturation and hematocrit are identified as key risk factors.
  • Routine coagulation screening is recommended for children with CHD, particularly cyanotic types, to mitigate morbidity and mortality.
Abstract

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