Adjuvant Treatment Approaches after Radical Prostatectomy with Lymph Node Involvement.

Area of Science:

• Oncology
• Urology

Background:

• Prostate cancer with lymph node involvement requires careful consideration of adjuvant treatment strategies.
• Adjuvant therapy aims to reduce the risk of disease recurrence after radical prostatectomy.

Purpose of the Study:

• To evaluate adjuvant treatment preferences in lymph node-positive prostate cancer patients.
• To assess the impact of adjuvant treatments on prostate-specific antigen (PSA) recurrence.

Main Methods:

• Retrospective analysis of patients with lymph node-positive prostate cancer from the Turkish Urooncology Association database.
• Evaluation of adjuvant treatment approaches including hormonal therapy and radiotherapy.
• Kaplan-Meier analysis to compare PSA recurrence-free survival.

Main Results:

• Patients receiving adjuvant treatment had fewer lymph nodes removed, higher positive surgical margins, and seminal vesicle invasion.
• A significant survival advantage was observed in patients receiving hormonal therapy combined with radiotherapy compared to other groups.
• No significant difference in 5-year PSA recurrence-free survival was found between patients with and without adjuvant therapy overall.

Conclusions:

• Adjuvant therapy in lymph node-positive prostate cancer did not significantly alter overall PSA recurrence-free survival.
• Hormonal therapy combined with radiotherapy demonstrated a survival benefit in a subgroup analysis.