Antagonistic and synergistic effects of lead and selenium in Rattus norvegicus

Female rats were administered intraperitoneal injections of solutions of lead acetate and sodium selenite. The salt solutions were given singly to 'control' animals and successively to the 'treated' animals in both chronic and acute treatments but with or without a time gap of 1 h in the latter treatment. In the chronic treatments the dosage of lead acetate was kept constant and that of sodium selenite varied while in the acute treatments the ratio of the two salts was kept constant. Degrees of protection afforded by sodium selenite against chromosomal damage caused by lead acetate were assessed.