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[Vaccination and Vaccination Response in Immunodeficiency]
Géraldine Blanchard Rohner1, Peter Jandus2
1Département de la femme, de l'enfant et de l'adolescent, Unité d'immunologie-vaccinologie pédiatrique, Hôpitaux Universitaires de Genève, Suisse.
Therapeutische Umschau. Revue Therapeutique
|July 29, 2022
Summary
Vaccinating immunocompromised patients presents challenges. However, all SARS-CoV-2 vaccines approved in Switzerland are safe for these individuals, despite potential difficulties in assessing immune response.
Area of Science:
- Immunology
- Vaccinology
- Infectious Diseases
Background:
- Vaccination in patients with immunodeficiencies is complex.
- Assessing vaccine response in immunocompromised individuals can be difficult.
- Primary immunodeficiency may be indicated by poor antibody titer increase or vaccine-induced infections.
Purpose of the Study:
- To review the challenges and considerations for vaccinating patients with immunodeficiencies.
- To provide guidance on SARS-CoV-2 vaccination for immunocompromised populations.
- To highlight the safety of available SARS-CoV-2 vaccines for this group.
Main Methods:
- Literature review on vaccination in immunodeficiency.
- Analysis of vaccine efficacy and safety data in immunocompromised patients.
- Review of Swiss guidelines for SARS-CoV-2 vaccination.
Main Results:
- Vaccination response in immunodeficient patients can be variable.
- Lack of antibody titer increase or infection post-vaccination may suggest underlying immunodeficiency.
- All SARS-CoV-2 vaccines licensed in Switzerland are deemed suitable for immunocompromised patients.
Conclusions:
- Immunocompromised patients can receive SARS-CoV-2 vaccines available in Switzerland.
- Careful monitoring and interpretation of vaccine response are necessary in this population.
- Further research may be needed to optimize vaccination strategies for specific immunodeficiencies.
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