[Hypogammaglobulinemia and Multiple Sclerosis - An Overlooked Correlation?]

Hypogammaglobulinemia and Multiple Sclerosis - An Overlooked Correlation? Abstract. Hypogammaglobulinemias occur in people with multiple sclerosis (MS) without immunotherapy in 8.1% of patients and with immunotherapy (not drug-specific) in up to 26.4% of affected individuals. This is thus significantly higher than the expected incidence in the general population. In MS patients it is also relevant to differentiate between primary and secondary hypogammaglobulinemia. In particular, anti-CD20 therapies are mainly underlying for the secondary forms in MS patients. With this article, we aim to provide a "spotlight" on hypogammaglobulinemia with a focus on the clinical consequence of these phenomena in people with MS.