Related Experiment Videos
Pseudoexfoliative material contains an elastic microfibrillar-associated glycoprotein.
Transactions of the American Ophthalmological Society
|January 1, 1986
Summary
PSX material shares components with zonular fibers, suggesting abnormal glycoprotein polymerization within the elastic microfibrillar system. Lens epithelial cells appear involved in processing this protein.
Area of Science:
- Ophthalmology
- Biochemistry
- Cell Biology
Background:
- Histochemical similarities suggest PSX material components are present in zonular fibers.
- The zonule is part of the elastic microfibrillar system.
Purpose of the Study:
- To investigate the immunologic affinity of PSX material to elastic microfibrillar protein (MFP).
- To determine if PSX material originates from the zonular-elastic microfibrillar system.
Main Methods:
- Indirect immunoperoxidase electron microscopy was used.
- PSX material on the lens capsule was tested against antibodies to elastic MFP from diverse sources.
Main Results:
- Positive staining was observed on all components of lens PSX material (superficial aggregates, deep fibrogranular zone, capsular inclusions).
- Antibodies to elastic MFP showed positive affinity to PSX material.
Conclusions:
- PSX material likely results from abnormal glycoprotein polymerization linked to the zonular-elastic microfibrillar system.
- Lens epithelial cells are implicated in processing this abnormal protein.
- Other microfibrillar-secreting cells may also produce similar material.