Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

367
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
367
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

301
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
301
Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

34
Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
34

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility and tolerability of reduced-volume oral sulfate solution combined with elobixibat for bowel preparation before colonoscopy: a single-center pilot study.

Gastroenterology report·2026
Same author

Concomitant short-term ingestion of fucoidan improves the initial inflammation and immune dysfunction caused by a high-fat diet.

Bioscience, biotechnology, and biochemistry·2026
Same author

Recurrent local and systemic hypersensitivity reactions after switching back from subcutaneous to intravenous vedolizumab in ulcerative colitis: a case presentation.

Gastroenterology report·2026
Same author

Tailored Synthesis of Doped Non-Layered Oxide Nanosheets Using Designed Solid-State Surfactants.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Severe Myenteric Plexitis at the Proximal Margin Predicts Postoperative Recurrence in Crohn's Disease Irrespective of Margin Distance.

Journal of the anus, rectum and colon·2026
Same author

Azathioprine withdrawal leading to spontaneous remission of Iatrogenic Epstein-Barr virus-negative diffuse large B-cell lymphoma: A case report and literature review.

Internal medicine (Tokyo, Japan)·2026

Related Experiment Video

Updated: Sep 3, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

12.7K

Atypical Splenic Abscesses Due to Clostridioides difficile.

Yukiko Komeno1, Takeru Iida1,2, Ayumu Kocha1,2

  • 1Department of Hematology, Japan Community Healthcare Organization (JCHO) Tokyo Yamate Medical Center, Shinjuku City, Tokyo, Japan.

The American Journal of Case Reports
|July 30, 2022
PubMed
Summary

This case report details a rare splenic abscess caused by Clostridioides difficile in an immunocompromised patient. Despite atypical imaging, diagnosis was confirmed post-splenectomy, highlighting C. difficile as an unusual cause of splenic abscess.

More Related Videos

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.2K
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.2K

Related Experiment Videos

Last Updated: Sep 3, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

12.7K
A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
09:12

A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection

Published on: June 15, 2018

10.2K
Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection
07:06

Fecal Microbiota Transplantation via Colonoscopy for Recurrent C. difficile Infection

Published on: December 8, 2014

27.2K

Area of Science:

  • Infectious Diseases
  • Gastroenterology
  • Radiology

Background:

  • Splenic abscess is a rare infectious disease, increasingly seen in immunocompromised patients.
  • Clostridioides difficile is a common cause of colitis but rarely causes extraintestinal infections like splenic abscess.

Observation:

  • A 90-year-old male presented with weight loss, fever, and abdominal pain.
  • CT and MRI revealed splenomegaly with atypical nodular lesions, lacking definitive diagnostic features.
  • Laparoscopic splenectomy was performed due to inconclusive imaging and technical challenges with biopsy.

Findings:

  • Splenic abscesses were confirmed pathologically, showing widespread abscesses with hemorrhage and necrosis.
  • Cultures identified a polymicrobial infection including Clostridioides difficile, Enterococcus faecium, and Bacteroides fragilis.
  • This represents the tenth reported case of splenic abscess attributed to Clostridioides difficile.

Implications:

  • Splenic abscesses, particularly those caused by C. difficile, can exhibit atypical imaging findings due to chronic inflammation and necrosis.
  • Early recognition and appropriate management are crucial, although treatment challenges exist, as seen with ineffective antibiotic therapy in this case.
  • This case underscores the importance of considering rare pathogens in splenic abscesses, especially in vulnerable patient populations.