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[Comparative biochemical parameters in deceased and living patients in a follow-up intervention study of
Insights
Key blood markers like sedimentation rate, blood sugar, ASAT, ALAT, and cholesterol indicate heart disease risk. Uric acid, hemoglobin, and creatinine aid in assessing disease severity and prognosis.
Area of Science:
- Cardiology
- Clinical Chemistry
- Diagnostic Medicine
Background:
- Heart and vessel diseases pose a significant health burden.
- Early and accurate diagnosis is crucial for effective management and prognosis.
- Routine laboratory diagnostics are often the first step in evaluating patients with suspected cardiovascular conditions.
Purpose of the Study:
- To analyze the diagnostic and prognostic value of various laboratory parameters in patients with suspected heart and vessel diseases.
- To establish correlations between specific biomarkers and the presence, severity, and outcome of cardiovascular diseases.
- To evaluate the utility of certain laboratory tests in differential diagnostics for cardiovascular conditions.
Main Methods:
- Analysis of laboratory-diagnostical spectrum in a cohort of patients with suspected heart and vessel diseases.
- Comparison of results with outcomes (survival status) in a follow-up study.
- Statistical analysis to determine the causal connection and prognostic significance of selected parameters.
Main Results:
- Sedimentation rate of erythrocytes, blood sugar, ASAT, ALAT, and total cholesterol showed a significant correlation with heart disease.
- Uric acid, hemoglobin/hematocrit, and serum creatinine were related to the severity and prognosis of cardiovascular disease.
- Leukocyte count, total serum protein, serum protein fractions, and electrophoresis lability tests did not yield significant findings for cardiovascular disease association.
Conclusions:
- Specific biomarkers (erythrocyte sedimentation rate, blood sugar, ASAT, ALAT, cholesterol, uric acid, hemoglobin, creatinine) are valuable for diagnosing and assessing cardiovascular disease.
- Certain extensive laboratory tests (leukocyte count, protein analysis, electrophoresis) may not be cost-effective for routine cardiovascular screening or prognosis.
- A differentiated approach to utilizing diagnostic methods is recommended for optimal patient care and resource allocation.
Abstract:
After the laboratory-diagnostical spectrum had been analysed by means of a representative check of probationer with a state suspected of heart and vessel diseases on the screen of the X-ray mass examination in longitudinal section and cross-section with derived conclusions the results had been checked by means of comparison with the dead and not dead of this population in the follow up. The parameter sedimentation rate of erythrocyte, blood sugar, the enzymes "ASAT" and "ALAT" and total cholesterol with stronger pronounced proneness could substantiate the causal connection to this population of persons suffering from a heart disease as well. Hence followed derived relations to the severe degree of heart and vessel disease and beside this to the prognostical estimation of the disease for the parameter uric acid, hemoglobin/hematocrit and creatinine in the serum. The number of leucocytes, the serum protein, the separation of fractions of serum protein and lability test of serum by electrophoresis did not result in any findings, which allowed any connection with heart and vessel diseases, also concerning the persons who died in the course of the study, so that the demand for a differentiated, well-aimed differential-diagnostical use of these expensive research methods also for this extreme situation is substantiated once more. The results are discussed in comparison as well as in connection with the results found out of the total check and in dependence of age and sexes.