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Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
Published on: November 5, 2019
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[Vaccination prophylaxis for recurrent invasive meningococcal diseases].
1Kommission für Infektionskrankheiten und Impffragen, Deutsche Akademie für Kinder- und Jugendmedizin e. V. (DAKJ), Chausseestr. 128/129, 10115 Berlin, Deutschland.
Summary
Recurrent invasive meningococcal disease risk is high after infection, especially with complement defects. Vaccination with 4CMenB and/or MenACWY is recommended post-infection, without prior complement screening.
Area of Science:
- Pediatrics
- Infectious Diseases
- Vaccinology
Context:
- Invasive meningococcal disease (IMD) carries significant morbidity and mortality.
- Recurrent infections, including with the same serotype, are a risk, particularly in individuals with complement deficiencies.
- Current vaccination guidelines require specific approaches for at-risk populations.
Purpose:
- To outline a recommended approach for preventing recurrent invasive meningococcal infections in children and adolescents.
- To provide guidance on timely vaccination strategies following an IMD episode.
- To clarify the necessity of pre-vaccination screening for complement deficiencies.
Summary:
- The Committee for Infectious Diseases and Vaccinations recommends immediate vaccination post-IMD for unvaccinated children and adolescents.
- Vaccination should include 4-valent meningococcal B (4CMenB) and/or serogroups A, C, W, and Y (MenACWY) vaccines.
- Screening for complement deficiencies before vaccination is not deemed necessary.
Impact:
- Enhances prevention strategies for invasive meningococcal disease.
- Reduces the risk of severe outcomes associated with recurrent meningococcal infections.
- Simplifies vaccination decision-making for healthcare professionals and patients.
Keywords:
Immunization protectionInvasive meningococcal diseaseMeningococci group A, B, C, W, YRecurrent invasive meningococcal infectionVaccinationMore Related Videos
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