Related Experiment Video

Updated: Sep 2, 2025

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery
10:03

Inducing Meningococcal Meningitis Serogroup C in Mice via Intracisternal Delivery

Published on: November 5, 2019

7.3K

[Vaccination prophylaxis for recurrent invasive meningococcal diseases]

Andreas Müller1,

  • 1Kommission für Infektionskrankheiten und Impffragen, Deutsche Akademie für Kinder- und Jugendmedizin e. V. (DAKJ), Chausseestr. 128/129, 10115 Berlin, Deutschland.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|August 1, 2022
PubMed

Insights

Recurrent invasive meningococcal disease risk is high after infection, especially with complement defects. Vaccination with 4CMenB and/or MenACWY is recommended post-infection, without prior complement screening.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Vaccinology

Context:

  • Invasive meningococcal disease (IMD) carries significant morbidity and mortality.
  • Recurrent infections, including with the same serotype, are a risk, particularly in individuals with complement deficiencies.
  • Current vaccination guidelines require specific approaches for at-risk populations.

Purpose:

  • To outline a recommended approach for preventing recurrent invasive meningococcal infections in children and adolescents.
  • To provide guidance on timely vaccination strategies following an IMD episode.
  • To clarify the necessity of pre-vaccination screening for complement deficiencies.

Summary:

  • The Committee for Infectious Diseases and Vaccinations recommends immediate vaccination post-IMD for unvaccinated children and adolescents.
  • Vaccination should include 4-valent meningococcal B (4CMenB) and/or serogroups A, C, W, and Y (MenACWY) vaccines.
  • Screening for complement deficiencies before vaccination is not deemed necessary.

Impact:

  • Enhances prevention strategies for invasive meningococcal disease.
  • Reduces the risk of severe outcomes associated with recurrent meningococcal infections.
  • Simplifies vaccination decision-making for healthcare professionals and patients.
Keywords:
Immunization protectionInvasive meningococcal diseaseMeningococci group A, B, C, W, YRecurrent invasive meningococcal infectionVaccination

More Related Videos

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection05:55

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Published on: May 7, 2020

8.3K
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens13:47

Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens

Published on: May 19, 2020

3.5K

Related Concept Videos

Vaccinations01:51

Vaccinations

Overview
45.2K
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
500
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
18
Transmission-based Precautions II: Airborne and Protective Environment01:25

Transmission-based Precautions II: Airborne and Protective Environment

Transmission-based precautions are for patients infected or suspected to be infected (or colonized) with organisms posing a significant risk to others. The transmission precautions include airborne and protective environment precautions.
Airborne precautions:
Use airborne precautions when treating patients known or suspected to have diseases that spread through the air—for example, tuberculosis or measles. These organisms are present in smaller droplets expelled by an infected person and...
1.4K
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
29
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.4K