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Updated: Sep 2, 2025

Isolating Nasal Olfactory Stem Cells from Rodents or Humans
Published on: August 22, 2011
Intranasally applied human olfactory mucosa neural progenitor cells migrate to damaged brain regions
John M Kronner1, Adam Folbe2, Jay Meythaler3
1Department of Ophthalmology, Visual & Anatomical Sciences, Wayne State University School of Medicine, Detroit, MI 48201, USA.
Aim:
To determine if intranasally administered olfactory mucosa progenitor cells (OMPCs) migrate to damaged areas of brain.
Materials & Methods:
Rowett Nude (RNU) adult rats were injured using the Marmarou model then 2 weeks later received intranasally-delivered human OMPC. After 3 weeks, rats were sacrificed and brain sectioned. The mean distances from the human OMPCs to markers for degenerative neuronal cell bodies (p-c-Jun+), axonal swellings on damaged axons (β-APP+) and random points in immunostained sections were quantified. One-way ANOVA was used to analyze data.
Results:
The human OMPCs were seen in specific areas of the brain near degenerating cell bodies and damaged axons.
Conclusion:
Intranasally delivered human OMPC selectively migrate to brain injury sites suggesting a possible noninvasive stem cell delivery for brain injury.
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