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Published on: June 21, 2017
The Alkynylative Difunctionalization of Alkenes
1School of Chemistry and Chemical Engineering Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.
This review summarizes alkene alkynylative difunctionalization methods. It covers alkynylation-initiated and alkynylation-terminated reactions, aiding further research in synthesizing alkynyl compounds.
Area of Science:
- Organic Chemistry
- Synthetic Chemistry
- Catalysis
Background:
- Alkynyl groups are crucial functional units in organic synthesis.
- Efficient methods for constructing alkynyl-containing compounds are highly sought after.
- Alkynylative difunctionalization of alkenes offers a direct route to these compounds.
Purpose of the Study:
- To provide a comprehensive review of alkene alkynylative difunctionalization strategies.
- To systematically categorize existing methods into alkynylation-initiated and alkynylation-terminated approaches.
- To stimulate further research and development in this field.
Main Methods:
- Literature review and systematic categorization of reported synthetic methodologies.
- Classification based on the sequence of alkynylation relative to other functionalization steps.
- Analysis of catalytic asymmetric approaches within the scope of difunctionalization.
Main Results:
- Detailed summary of various alkynylative difunctionalization reactions of alkenes.
- Organization of methods into two primary categories: alkynylation-initiated and alkynylation-terminated.
- Highlighting the progress and advancements, particularly in catalytic asymmetric variants.
Conclusions:
- Alkynylative difunctionalization of alkenes is a rapidly advancing area in organic synthesis.
- This review consolidates current knowledge, providing a valuable resource for researchers.
- The comprehensive summary is expected to foster innovation and exploration in synthesizing alkynyl compounds.
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