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Technical Report: Automatic Measurement of Corneal Nerve Fiber Area Using Versatile Software
Koichiro Shinji1, Taiichiro Chikama, Yoshiaki Kiuchi1
1Department of Ophthalmology and Visual Science, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.
Summary
Automated software accurately measures corneal nerve fiber area, comparable to manual analysis by experts. This tool shows promise for quantifying various corneal structures in research and clinical settings.
Area of Science:
- Ophthalmology
- Medical Imaging
- Corneal Science
Background:
- In vivo confocal microscopy is a key technique for examining corneal structures.
- Measuring corneal structure areas is a valuable research index.
- Commercial software offers automated analysis of these structures.
Purpose of the Study:
- To assess the precision of software in quantifying corneal nerve fiber area.
- To validate automated measurements against expert manual analysis.
Main Methods:
- Corneal nerve fiber areas were automatically measured using specialized software on images from 11 healthy volunteers.
- An ophthalmologist performed manual measurements for comparison.
- Pearson correlation analysis evaluated the agreement between automated and manual measurements and age correlation.
Main Results:
- A high correlation (r = 0.98) was observed between automated and manual corneal nerve fiber area measurements.
- Corneal nerve fiber area showed no significant correlation with participant age for either measurement method.
Conclusions:
- The software provides accurate automated measurements of corneal nerve fiber area, matching expert manual analysis.
- This automated software is a reliable tool for quantifying corneal structures in research and clinical applications.
