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How do I/we forecast tomorrows' transfusion: Blood components.

Nicolas Pereyra1, Dana V Devine2

  • 1Department of Biochemistry and Molecular Biology, The University of British Columbia, Canada; The University of British Columbia Centre for Blood Research, Vancouver, Canada.

Transfusion Clinique Et Biologique : Journal De La Societe Francaise De Transfusion Sanguine
|August 1, 2022
PubMed
Summary

Pathogen Reduction Technologies (PRTs) reduce transfusion risks but may increase demand for blood products. Innovations in platelet storage and whole blood transfusions offer potential improvements in transfusion efficacy and supply.

Keywords:
Pathogen reductionStorage

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Area of Science:

  • Transfusion Medicine
  • Blood Product Safety
  • Pathogen Reduction Technologies

Background:

  • Current Pathogen Reduction Technologies (PRTs) present a dual impact on transfusion medicine.
  • PRTs offer a standardized approach to mitigate transfusion-transmitted infections and immune responses.
  • Concerns exist regarding the potential reduction in transfusion efficacy of PRT-treated products.

Purpose of the Study:

  • To evaluate the advantages and disadvantages of Pathogen Reduction Technologies in transfusion medicine.
  • To explore alternative strategies for improving blood product quality and availability.
  • To assess the impact of PRTs on the demand and supply of blood products.

Main Methods:

  • Review of current literature on Pathogen Reduction Technologies.
  • Analysis of the efficacy and safety data of PRT-treated blood products.
  • Examination of emerging transfusion strategies, including cold-stored platelets and whole blood.

Main Results:

  • PRTs effectively reduce transfusion-transmitted infections and immune reactions.
  • A potential decrease in the transfusion efficacy of PRT-treated products may increase overall demand.
  • Cold-stored platelets and whole blood transfusions are re-emerging as viable options.

Conclusions:

  • Pathogen Reduction Technologies offer significant safety benefits but may strain blood supply due to reduced efficacy.
  • Innovations in platelet storage and whole blood transfusions present promising avenues for enhancing transfusion outcomes.
  • Focusing on donor variability, storage quality, and transfusion outcomes can improve both quality and supply in transfusion medicine.