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Updated: Sep 2, 2025

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes

Published on: April 10, 2015

Bimetallic Ruthenium Nitrosyl Complexes with Enhanced Two-Photon Absorption Properties for Nitric Oxide Delivery.

Yael Juarez-Martinez¹, Pablo Labra-Vázquez^1,2, Alejandro Enríquez-Cabrera^1,2

¹Laboratoire de Chimie de Coordination du CNRS, 205 route de Narbonne, F-31077, Toulouse, France.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|August 2, 2022

Summary

This study introduces novel bimetallic ruthenium nitrosyl (RuNO) complexes with enhanced two-photon absorption properties. These RuNO complexes show potential for targeted drug delivery applications due to their ability to release nitric oxide (NO⋅) upon irradiation.

Keywords:

density functional calculations ligand design photochemistry ruthenium nitrosyl two-photon absorption

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Published on: February 16, 2022

Area of Science:

Inorganic Chemistry
Photochemistry
Materials Science

Background:

Ruthenium nitrosyl (RuNO) complexes are investigated for their unique photochemical properties.
Developing novel bimetallic complexes can lead to enhanced functionalities compared to monometallic counterparts.
Fluorenyl-substituted terpyridine ligands offer tunable electronic and structural properties.

Purpose of the Study:

To synthesize and characterize new monometallic and bimetallic RuNO complexes.
To investigate the spectroscopic properties, particularly one-photon absorption (OPA) and two-photon absorption (TPA), of these complexes.
To explore the potential of these RuNO complexes for TPA-based drug delivery applications.

Main Methods:

Synthesis and full characterization of novel RuNO complexes.
Crystallographic analysis of selected bimetallic complexes.
Spectroscopic studies including OPA and TPA measurements.
Time-dependent density-functional theory (TD-DFT) computations.

Main Results:

One monometallic and three bimetallic RuNO complexes featuring fluorenyl-substituted terpyridine ligands were successfully synthesized.
Crystal structures of bis-RuNO2 and bis-RuNO complexes with the TFT ligand were determined.
Spectroscopic data showed good correlation with TD-DFT calculations for OPA.
Bimetallic complexes exhibited a significant enhancement in TPA cross-section (σTPA), reaching up to 1523±98 GM at 700 nm.
All synthesized compounds demonstrated nitric oxide (NO⋅) release upon irradiation.

Conclusions:

The bimetallic RuNO complexes display significantly enhanced TPA properties within the biological therapeutic window.
The ability of these complexes to release NO⋅ under irradiation suggests promising applications in TPA-based photodynamic therapy and drug delivery systems.