Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inhalation toxicity studies with 1,3-butadiene. 3. Two year toxicity/carcinogenicity study in rats.

P E Owen, J R Glaister, I F Gaunt

    American Industrial Hygiene Association Journal
    |May 1, 1987
    PubMed
    Summary

    This study found that butadiene exposure in rats led to an increased incidence of various tumors, including uterine, mammary, and thyroid tumors, suggesting it is a weak oncogen. Further research is needed to understand human health risks.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Exercise-induced mitochondrial dysfunction in an elite athlete.

    Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine·1998
    Same author

    Oxalate nephrosis in Macaca fascicularis.

    Laboratory animals·1994
    Same author

    Inhalation toxicity and carcinogenicity of 1,3-butadiene in Sprague-Dawley rats.

    Environmental health perspectives·1990
    Same author

    Teratogenicity and embryotoxicity study of Brown HT in the rat.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·1987
    Same author

    Metabolic disposition of 14C-labelled Brown HT in the rat, mouse and guinea-pig.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·1987
    Same author

    Chronic toxicity/carcinogenicity study of carmine of cochineal in the rat.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·1987

    Area of Science:

    • Toxicology
    • Oncology
    • Industrial Hygiene

    Background:

    • Butadiene is a widely used industrial chemical.
    • Understanding its carcinogenic potential is crucial for occupational safety.

    Purpose of the Study:

    • To evaluate the oncogenic effects of chronic butadiene exposure in rats.
    • To determine dose-response relationships for butadiene-induced tumors.

    Main Methods:

    • Male and female rats were exposed to 0, 1000, or 8000 ppm butadiene for 6 hours/day, 5 days/week.
    • Animals were observed for tumor development and other health effects until predicted survival dropped significantly.
    • Histopathological examination was performed to identify tumor types and other pathologies.

    Main Results:

    Related Experiment Videos

    • Increased incidences of pancreatic exocrine adenoma, uterine sarcoma, Zymbal gland carcinoma, mammary tumors, thyroid follicular cell tumors, and testis Leydig-cell tumors were observed.
    • High-dose exposure led to increased mortality in females due to subcutaneous masses and in males due to nephropathy.
    • No significant effects were noted in hematology or neuromuscular function tests.

    Conclusions:

    • Butadiene demonstrated weak oncogenic activity in rats under the tested exposure conditions.
    • The study identified specific tumor types associated with butadiene exposure, highlighting potential human health concerns.