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Oxalate nephrosis in Macaca fascicularis
P N Skelton-Stroud1, J R Glaister
1Ciba Pharmaceuticals, Wilmslow, Cheshire, United Kingdom.
Laboratory Animals
|July 1, 1994
Summary
Calcium oxalate monohydrate crystals were found in the kidneys of cynomolgus monkeys. The exact cause for these kidney crystals remains undetermined, though incidence varied among animal groups.
Area of Science:
- Nephrology
- Primate Pathology
- Mineralogy
Background:
- Renal calculi and crystal deposition are significant health concerns in various species.
- Understanding crystal formation in non-human primates can provide insights into comparative nephrology.
Purpose of the Study:
- To characterize the nature of crystals found in the renal proximal convoluted tubules of cynomolgus monkeys.
- To investigate the potential causes and incidence of these renal crystals.
Main Methods:
- Light microscopy
- Scanning electron microscopy (SEM)
- Histochemical staining
- X-ray microanalysis
Main Results:
- Crystals identified as calcium oxalate monohydrate based on physical structure and staining.
- Microscopic analysis revealed crystal presence within the renal proximal convoluted tubules.
- Incidence of crystals varied significantly between different batches of cynomolgus monkeys.
Conclusions:
- The identified renal crystals are composed of calcium oxalate monohydrate.
- No definitive cause for the crystal formation was established in this study.
- Further research is warranted to explore the factors influencing calcium oxalate crystal deposition in this primate model.