Related Experiment Video
Updated: Sep 2, 2025

Voltage Biasing, Cyclic Voltammetry, & Electrical Impedance Spectroscopy for Neural Interfaces
Published on: February 24, 2012
Comparison and Integration of Voltage and Charge Amplifiers for Capacitive ECG Measurements
Objective:
Sensing with capacitive electrodes is of interest for long-term, comfortable bio-potential measurements (e.g., ECG). However, due to the small body-to-electrode capacitance (Ce), the design of the associated front-end amplifier remains a challenge. Both voltage amplifiers (VA) and charge amplifiers (CA) can be employed. While basic comparisons of both typologies were done before, this paper extends the comparison to their responses to artifacts (caused by motion or interference). Further, a VA-CA-switchable amplifier is proposed, allowing to adapt the amplifier type to different situations, and enabling to estimate the body-to-electrode capacitance Ce in a passive way.
Methods:
A VA-CA switchable amplifier was implemented in a 180 nm CMOS process. The responses to artifacts for VA and CA were studied by modelling, simulations and experiments using the custom IC. The proposed Ce estimation method was validated by electrical tests and in-vivo tests.
Results:
VAs are less affected by Ce variation artifacts, while CAs recover faster from triboelectricity artifacts. In a VA, these two artifacts are multiplicative and get modulated if they occur simultaneously, but in a CA they remain independent.
Conclusion:
The combined VA-CA amplifier has the potential for optimal amplifier selection according to the properties of the recorded signal, the value of Ce and the actual presence of artifacts. Moreover, it can estimate Ce without extra hardware.
Significance:
The proposed VA-CA switchable structure is superior to an individual VA or CA, thanks its adaptability to signal quality and artifacts, and it provides extra information on the body-to-electrode interface quality (Ce).
Related Concept Videos
Instrumentation Amplifier
To overcome this challenge, an ECG machine utilizes an instrumentation amplifier. This specialized amplifier is...
Design Example: Capacitance Multiplier Circuit
The circuit illustrated in Figure 1 below incorporates two op-amps, with the first operating as a voltage follower and the second acting as an inverting amplifier.
Bode Plots Construction
Capillary Electrophoresis: Instrumentation
Equivalent Capacitance
The following strategies are adopted to calculate...
Capacitors in Series and Parallel
Suppose the capacitors are connected one after the other such that the negative terminal of the first connects to the positive terminal of the...

