The underlying mechanism of PM2.5-induced ischemic stroke

Under the background of global industrialization, PM_2.5 has become the fourth-leading risk factor for ischemic stroke worldwide, according to the 2019 GBD estimates. This highlights the hazards of PM_2.5 for ischemic stroke, but unfortunately, PM_2.5 has not received the attention that matches its harmfulness. This article is the first to systematically describe the molecular biological mechanism of PM_2.5-induced ischemic stroke, and also propose potential therapeutic and intervention strategies. We highlight the effect of PM_2.5 on traditional cerebrovascular risk factors (hypertension, hyperglycemia, dyslipidemia, atrial fibrillation), which were easily overlooked in previous studies. Additionally, the effects of PM_2.5 on platelet parameters, megakaryocytes activation, platelet methylation, and PM_2.5-induced oxidative stress, local RAS activation, and miRNA alterations in endothelial cells have also been described. Finally, PM_2.5-induced ischemic brain pathological injury and microglia-dominated neuroinflammation are discussed. Our ultimate goal is to raise the public awareness of the harm of PM_2.5 to ischemic stroke, and to provide a certain level of health guidance for stroke-susceptible populations, as well as point out some interesting ideas and directions for future clinical and basic research.