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Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents
Published on: January 10, 2014
Effect of time-dependent ibuprofen administration on the post operatory after impacted third molar extraction: a
Fabián Pérez-González1, Mohammad Abusamak2, Luis Miguel Sáez-Alcaide3
1Faculty of Dentistry, Department of Dental Clinical Specialties, University Complutense of Madrid, Plaza Ramón y Cajal S/N, 28040, Madrid, Spain. fabianpe@ucm.es.
Purpose:
To evaluate time-dependent administration of ibuprofen in a lower third molar extraction model.
Methods:
Eleven patients requiring bilateral surgical removal of lower third molars were recruited and randomized into a blinded crossover randomized controlled trial. For 3 days after surgery, the control group was prescribed ibuprofen 400 mg every 8 h. On the other hand, the experimental group received also ibuprofen 400 mg at breakfast and lunch, replacing the dinner intake with a placebo. Pain measurements (Visual Analog Scale from 0 to 10) were recorded at baseline, 24, 48, and 72 h postoperatively. Facial swelling and trismus were also measured at baseline, 24, and 72 h postoperatively.
Results:
Postoperative swelling and pain perception did not show significative difference between the control and experimental groups at 24, 48, and 72 h. Trismus was significantly lower in the control group than in the experimental group at 72 h postoperatively (p = 0.008). Rescue medication consumption seemed to be comparable between groups.
Conclusion:
Eliminating night time ibuprofen might be insignificant for pain control after third molar extraction.
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