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Association of the Interleukin-10-592C/A Polymorphism and Cervical Cancer Risk: A Meta-Analysis.

Brehima Diakite¹, Yaya Kassogue¹, Mamoudou Maiga^1,2,3

¹Centre de Recherche et de Formation sur les Pathologies Moleculaires (CREFPAM), University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako, Mali.

Genetics Research

|August 3, 2022

Summary

The IL-10 gene -592C/A polymorphism increases cervical cancer risk, particularly in Asian populations. This meta-analysis confirms its role as a significant risk factor across various genetic models.

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Area of Science:

Genetics
Oncology
Epidemiology

Background:

Discrepancies exist regarding the association between the IL-10 gene -592C/A polymorphism and cervical cancer risk.
A comprehensive meta-analysis is needed to consolidate existing data and provide more precise conclusions.

Purpose of the Study:

To investigate the relationship between the IL-10 gene -592C/A polymorphism and cervical cancer risk.
To perform a meta-analysis of published studies to increase statistical power and generalizability.

Main Methods:

A meta-analysis was conducted on eleven studies comprising 4187 cases and 3311 controls.
Fixed-effects or random-effects models were used to calculate pooled odds ratios (ORs).
Heterogeneity and bias were assessed using inconsistency tests and funnel plots.

Main Results:

The -592C/A polymorphism of the IL-10 gene was associated with an increased susceptibility to cervical cancer across recessive, dominant, and additive genetic models (ORs ranging from 1.25 to 1.36).
Significant associations were observed in Asian populations for all genetic models and in Caucasian populations for recessive and additive models (P < 0.05).

Conclusions:

The IL-10 gene -592C/A polymorphism is a potential risk factor for cervical cancer.
The genetic polymorphism shows a significant association with elevated cervical cancer risk, especially in Asian populations.