Related Experiment Video

Updated: Sep 2, 2025

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

1.8K

Atrial amyloidosis: mechanisms and clinical manifestations

Giuseppe Vergaro1,2, Alberto Aimo1,2, Claudio Rapezzi3,4

  • 1Interdisciplinary Center Health Science, Scuola Superiore Sant'Anna, Pisa, Italy.

European Journal of Heart Failure
|August 3, 2022
PubMed

Insights

Cardiac amyloidosis (CA) involves atrial amyloidosis, an early sign linked to heart failure, atrial fibrillation, and clots. It can occur in isolation, impacting heart function and patient outcomes.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Biomedical Science

Background:

  • Cardiac amyloidosis (CA) is a significant cause of heart failure.
  • Amyloid deposition occurs throughout cardiac structures, not just the ventricles.
  • Atrial involvement is an early manifestation of CA.

Purpose of the Study:

  • To review the mechanisms of atrial amyloidosis in cardiac amyloidosis.
  • To discuss the clinical relevance and implications of atrial amyloidosis.
  • To highlight isolated atrial amyloidosis as a distinct entity.

Main Methods:

  • Literature review of existing evidence on atrial amyloidosis.
  • Synthesis of data on amyloid infiltration and its effects on atrial structures.
  • Analysis of clinical associations, including atrial fibrillation and thromboembolism.

Main Results:

  • Atrial amyloidosis contributes to diastolic dysfunction and atrial enlargement.
  • It increases the risk of atrial fibrillation and thromboembolic events.
  • Isolated atrial amyloidosis, linked to natriuretic peptide overproduction, can occur without ventricular disease.

Conclusions:

  • Atrial amyloidosis is a crucial, often early, component of cardiac amyloidosis with significant clinical consequences.
  • Understanding atrial involvement is key for managing heart failure and preventing complications.
  • Further research into isolated atrial amyloidosis mechanisms and management is warranted.

Keywords:
AmyloidosisAtrial diseaseAtrial fibrillationHeartNatriuretic peptides

More Related Videos

Rapid Generation of Amyloid from Native Proteins In vitro05:48

Rapid Generation of Amyloid from Native Proteins In vitro

Published on: December 5, 2013

6.2K
Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction08:31

Isolation of Atrial Cardiomyocytes from a Rat Model of Metabolic Syndrome-related Heart Failure with Preserved Ejection Fraction

Published on: July 26, 2018

10.2K

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.8K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
47
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
40
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
19
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
49
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
20