Palladium metallaphotoredox-catalyzed 3-acylation of indole derivatives
Xinmou Wang1, Mo Yu1, Hongjian Song1
1State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, People's Republic of China. wangqm@nankai.edu.cn.
Abstract:
3-Acylindole motifs are wildly found in pharmaceuticals and biologically active alkaloids. Synthesis of this motif from aldehydes and indoles via dehydrogenative cross-coupling (CDC) reactions is the most efficient pathway. Here, we report a method for synthesis of 3-acyl indoles from aldehydes by a combination of photocatalysis and palladium catalysis. This mild, robust method is compatible with a wide array of functional groups and has a broad substrate scope. Our findings may inspire the development of new CDC reactions.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
10:42Preparation of N-2-alkoxyvinylsulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
Published on: January 3, 2018
Related Concept Videos
Vicinal Diols via Reductive Coupling of Aldehydes or Ketones: Pinacol Coupling Overview
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Cycloaddition Reactions: Overview
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Cycloaddition Reactions: MO Requirements for Photochemical Activation
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
