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Published on: July 21, 2017
Stimuli-responsive spin crossover nanoparticles for drug delivery and DNA-binding studies
Christina D Polyzou1, Patroula Gkolfi1, Christos T Chasapis2
1Department of Chemistry, Laboratory of Inorganic Chemistry, University of Patras, 26504 Patras, Greece. chpolyzou@upatras.gr.
Abstract:
Aminated silica hybrid, spin-crossover (SCO) nanoparticles (AmNPs) coupled with (S)-naproxen (NAP) were proposed for potential drug nanocarriers through drug release experiments at various pH values. DNA- and albumin-binding studies were also carried out using diverse techniques in order to investigate the interaction of the nanoparticles with calf-thymus DNA and serum albumins and to determine the corresponding binding constants.
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