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Circulating short-chain fatty acids in type 2 diabetic patients and overweight/obese individuals
Dominic Salamone1, Giuseppina Costabile1,2, Alessandra Corrado1
1Department of Clinical Medicine and Surgery, "Federico II" University, Sergio Pansini, 5, 80131, Naples, Italy.
Aim:
aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in patients with Type 2 diabetes (T2D) and overweight/obese individuals.
Methods:
In forty-three patients with T2D and twenty-eight overweight/obese patients SCFA were determined by Gas-Chromatography/Flame Ionization Detector (GC/FID).
Results:
Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model. Adjusting for all variables only propionic acid remained significantly lower in T2D.
Conclusion:
Only reduction of propionic acid was closely related to diabetes itself, regardless of all other factors.
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