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Mean platelet volume and platelet distribution width in the neonate
The American Journal of Pediatric Hematology/Oncology
|January 1, 1987
Summary
Established normal reference ranges for mean platelet volume (MPV) and platelet distribution width (PDW) in neonates are crucial. This study found significant variations in MPV and PDW between term and preterm infants, correlating with gestational age and birth weight.
Area of Science:
- Neonatal Hematology
- Pediatric Blood Research
Background:
- Establishing normal reference ranges for hematological parameters in neonates is essential for accurate diagnosis and monitoring.
- Mean platelet volume (MPV) and platelet distribution width (PDW) are important indicators of platelet activation and function, but their normal values in newborns are not well-defined.
Purpose of the Study:
- To determine and establish normal reference ranges for MPV and PDW in healthy term and preterm neonates.
- To investigate the correlation of MPV and PDW with gestational age and birth weight in the neonatal population.
Main Methods:
- Analysis of cord blood samples from 143 healthy newborns (78 term, 65 preterm) using a Coulter counter.
- Statistical analysis to compare MPV and PDW values between term and preterm infants and to assess correlations with gestational age and birth weight.
Main Results:
- Platelet count and MPV were significantly higher in term infants compared to preterm infants (p<0.05 and p<0.001, respectively).
- PDW was significantly lower in term infants compared to preterm infants (p<0.001).
- Platelet count and MPV showed positive correlations with gestational age and birth weight, while PDW exhibited a significant negative correlation with both (p<0.001).
Conclusions:
- This study provides crucial reference ranges for MPV and PDW in neonates.
- Significant variations in MPV and PDW exist between term and preterm infants, influenced by gestational age and birth weight, highlighting the need for age-specific reference values.