Construction of 3,12-Diazatetracyclododecane-dienes through Unexpected Visible-Light-Induced Radical Cascade
Qidi Zhong1, Yinxin Wang1, Hanyang Lan1
1School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei 063210, China.
Abstract:
A novel visible-light-induced cascade radical cyclization reaction of 3-cyano-4-aryl-1,4-dihydropyridines for the construction of 3,12-diazatetracyclododecane-diene derivatives is reported for the first time. In the presence of 410 nm blue LED lamp as the light source and ethanol as the solvent, the reactions proceed smoothly to afford photocyclization products in good yields. The process is carried out through the breaking of original C═C double bonds and the formation of three new single bonds in one pot and proved to be able to tolerate different substituents.
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